Scientific Program

Day 1

KEYNOTE SPEAKERS
  • Personalized treatment of chronic diseases from a computational perspective

    University of Milano-Bicocca
    Italy
    Biography

    Fabio Sartori, Ph.D., is an Assistant Professor at the Department of Computer Science, Systems and Communication, University of Milan-Bicocca, Milan. His research mainly focuses on conceptual and computational frameworks for knowledge-based systems design and implementation and case-based reasoning. He is the author and co-author of more than 70 scientific papers on international journals and conference proceedings. He is associate editor of Data Technologies and Applications journal and member of the steering committee of the Metadata and Semantics Conference Series.

    Abstract

    Quality of life (QoL) of patients affected by chronic diseases and their caregivers is a very important and interdisciplinary research topic. From recent literature new methodologies to reduce the impact of a chronic disorders on everyday life of affected people and their relatives are required: PERsonal Care Instructor and VALuator (PERCIVAL) project is an attempt to build up an integrated environment to promote the sharing, deliberation and monitoring of decisions about different aspects of chronic diseases among all the actors involved. Patients affected by chronic diseases are often interested by multiple disorders, which make them frail from many points of view: From the physical perspective, they must follow different kinds of therapies, with possible negative intersections that could cause them very hard side-effects; From the psychological standpoint, the self-acceptation of such long-term disability, and, for most of them, life-long disability, is very difficult to reach; Last, but not least, from the social viewpoint, they must entirely depend on their caregivers, that are their relatives most of the times, for all the aspects related to their condition; this dependency typically becomes closer and closer according to the evolution of the chronic disease. PERCIVAL aims at developing decision support systems capable to exploit both quantitative data perceived by wearable devices, that are nowadays recognized as very useful to face with chronic disorders and qualitative data provided by the user to take decisions tailored on patient profile. In this talk, the general architecture and a prototype of the PERCIVAL system focusing on the definition of personalized training programs will be presented. Moreover, the conceptual model behind the system, based on the adoption of bayesian networks and the first experiments, whose goal was to profile potential users of the PEERCIVAL system to derive effective Conditional Probability Tables will be introduced.

  • The Impact of the micro-nutitional diet on psychophysical well-being and human health

    University of Padua
    Italy
    Biography

    Claudio Frasson has been a doctor for over 20 years, deal with nutrition since 9. He was a general surgeon in Italy and the USA, He has often been in the United States to deepen my skills. In 2010 he graduated from Master's Degree in Population Nutrition and Food Safety and became a nutritionist. During the master he have mainly studied the skills on human micronutrition; subsequently he was a speaker several times at the international NUTRIMI congress, He wrote in Italian magazines for national dissemination, but above all he forged himself with the title of contract professor from 2013 at the Master 2 level in Food quality and safety University of Padua. He's co-supervisor of numerous Master's theses. In 2013 he was invited to report on micronutrition at the Miller school of Miami Diabetes Institute.

    Abstract

    Essential micronutrients (EMNs) are defined as nutrients that cannot be synthesized by an organism and are more easily acquired through the diet. Minerals, which are obviously essential micronutrients, are cofactors or integral elements for at least one of our organism's proteins. Therefore, it is not very important to differentiate macronutrients in diets, but rather to take various foods, optimizing, increasing, the contribution of EMN: all this is fundamental, for maintaining the optimal state of health. I applied these principles, based on the Mediterranean diet, on a fair number of patients 602 from 2012 to today obtaining excellent results (about 98%), for those who have admitted to having followed the food plan precisely , on relevant signs or symptoms that affect their sexual and social work life. These patients decreased mass and water retention, increasing mass and basal metabolism and breaking down visceral fat, falling in most cases. The group I bring for example 56 patients with essential arterial hypertension who have reduced or even stopped their drug therapy; 57 with various dyslipidemias that had similar benefits to those for hypertension, with the discontinuation of the use of statins in 90% of cases; 18 patients with type 2 diabetes had benefits on basal blood glucose and on a drastic reduction in the percentage of glycated hemoglobin, and consequently the decrease in drug therapy. In conclusion, the micro nutritional diet based on the Mediterranean diet, rarely offered both by specialists in the sector and by media around the world, as well as having a vast literature to confirm its validity, is a great way to eat healthy and nutritious that it certainly brings psycho socio-economic benefits, but basically maintains an optimal and long-lasting state of health.

  • Development of Therapeutic Drug for type 1 Diabetes

    Kitasato University
    Japan
    Biography

    Dr. Kazuichi Nakamura has experience in working for a pharmaceutical company for about 25 years. His specialization area is immunotoxicology. He started his current career in researching and teaching in the veterinary school, 2014. Since then, he has been being enthusiastic to develop therapeutic drugs for autoimmune diseases based on his experience in drug development and his knowledge in immunology. KVT-1 is one of the results of his research over the past 5 years in Kitasato University. He does not think that immunoenhancement cause autoimmune diseases. Immunoenhancement is a consequence of autoimmune diseases. Therefore he did not take immunosuppressive approaches, but tried to modulate the immunological condition behind the disease. As he believes combination therapy is more effective for remission of type 1 diabetes, he is now seeking for several opportunities of collaboration. The final goal of his research is obviously to improve the patients’ quality of life.

    Abstract

    Autoimmune diseases are classified into two types; Th1 type and Th2 type in both of which Th1/Th2 balance is skewed to either side. We aimed to normalize the skewed Th1/Th2 balance in type 1 diabetes, one of Th1 type autoimmune diseases. Some foreign protein derived from living organism with a code number KVT-1 was injected along with adjuvant to NOD mice, a murine model for type 1 diabetes, at 4 weeks of age. We successfully inhibited lymphocyte infiltration in and around pancreatic islets in NOD mice after administration of KVT-1. Even single dose of KVT-1 worked with adjuvant. The target mechanism of current marketed immunomodulatory drugs is to deplete T lymphocytes in inflammation lesions or to suppress inflammatory cytokines. These drugs may cause infectious diseases. KVT-1, however, does not pose such concern, because KVT-1 is intended to simply normalize the immune system from the skewed Th1/Th2 balance in type 1 diabetes. KVT-1 is a group of large molecule foreign antigens to humans as well as to mice. Allergic responses may be generated in clinical setting. KVT-1 would be formulated with adjuvant not to enhance immunological reactions but to sustain gradual release of KVT-1 from the local injection site, which should prevent anaphylaxis in the patients. No IgE class antibody against KVT-1 was detected in NOD mice after single dose along with adjuvant. KVT-1 can be a curative medicine for type 1 diabetes which is unmet need of the therapy. Although the anaphylaxis risk is considered to be minimum if KVT-1 is administered once along with adjuvant, it is preferable to identify the most effective part (epitope) of KVT-1 and to downsize its body. In addition, the combination therapy with another class of drug is expected to be more effective.

  • Deliberations on the Development of Mobile Phone Apps to Support Diabetes Self-Management: A Review from a Designer’s Perspective

    Oslo Metropolitan University
    Norway
    Biography

    Julia Jacoby is currently writing her PhD at the Nordic Norwegian University of Science and Technology (NTNU), while working at Oslo Metropolitan University. She is educated as a product designer in the two converging fields of Health and Design. She is particularly interested in how patients cope with chronic illness over long periods of time and how design can benefit this experience.

    Abstract

    Diabetes is a chronic illness with significant health consequences, especially for those who are unable to adhere to the complex treatment regimen. Self-management tasks such as regular medication and insulin use, frequent blood sugar checks, strict diet management, and consistent exercise can be quite challenging. Mobile technologies, specifically mobile applications (apps), present a unique opportunity to help patients improve adherence to these behaviors. The availability of commercial diabetes self-management apps is increasing rapidly, making it difficult for patients and providers to stay informed about app options. A number of reviews have described commercial app technology and use for patients with diabetes. This article provides a systematic review examining the factors considered in trials which engage mobile phone apps for diabetes self-management. The reason for reviewing such trials is to gain an understanding of what developmental considerations were adopted in these trials. This gives insight into what has been considered by other researchers in the past and can give insight into what can be valuable measures to adopt in the future. In addition these insights will be used to compare and contrast with findings from the actual market situation found in the two largest app stores Google Play and iTunes. In order to lay the ground work for an ethnographic fieldwork study in which diabetes patients will be asked about the use of self-tracking diabetes apps in the management of their diabetes in daily life. In order to achieve this a search was implemented across four electronic databases; Medline, Scopus, Social Science Citation Index, and CINALHL. The findings from these databases were reviewed based on the Joanna Briggs Checklist for Systematic Reviews. With the added query of whether Design, Interaction Design or Graphic Design were considered in the trials.

  • Application of Data Analytics in Healthcare to Serve the Mankind

    Nitte Meenakshi Institute of Technology
    India
    Biography

    Dr. Jharna Majumdar is currently the Dean R & D, Prof. Dept of M Tech Comp Sc. & Engg. and Head, Centre for Robotics Research at the Nitte Meenakshi Institute of Technology, Bangalore, India. Dr. Majumdar served Defense Research & Development Organization, Govt. of India from 1990 to 2007, worked as a Research Scientist on ‘Robotics and Automation’ at the Forschungs Zentrum Informatik, Karlsruhe, Germany from 1983 to 1989 and as a Research Scientist at the Stanford Research International California, USA in 2002. Dr. Majumdar has a PhD in Electrical Engg., Undergraduate and Post Graduate Engineering from IIT Kharagpur, India. Dr. Majumdar published more than 180 reviewed technical papers, has 4 Patents and received a large number of awards. Some of her worth mentioning awards are : Award from President, Stanford Research International (SRI International), California, USA, Performance Excellence Award from the Prime Minister of India, Dr V M Ghatage award from Aeronautical Society of India, Dr. Suman Sharma Award from National Design and Research Forum (NDRF), Dr. Kalpana Chawla Memorial Lecture Award etc. Her current research areas include Real Time Image and Video Processing, Data and Video Analytics, Robotics and Autonomous Systems, Artificial Intelligence, Machine Learning, ANN and Deep Learning

    Abstract

    As we are the era of rapid technological advancement, the data is increasing rapidly and the emerging technologies are used for a better solution. Due to the busy lifestyle, the focus and care on the health issues is neglected and is leading to severe health concerns at a later stage if not properly monitored and detected at an early stage. To overcome this problem and create an awareness among the individuals, a research is proposed to serve the Mankind using Data Analytics. Data Analytics involves a large volume and variety of data and helps us to examine the medical data and draw timely conclusions so that the patients can be sent regular alerts based on monitoring their health conditions. This work also helps the doctors to diagnose the disease at an early stage and prevents the patients from suffering at a later stage by adopting smart decision and right management techniques. This research involves the examination of the symptoms, previous health reports, treatment history of the patients and treatment record of similar disease which helps in deriving accurate conclusions and gives a way forward towards adopting the preventive measures. This work also leads to the confidentiality and data privacy challenges as the medical data being examined is to be restricted among the patients and doctors. The motivation behind this work is to serve the mankind and help them to lead a happy and healthy balanced life.

  • Data Analyses with ImageJ Software in Diabetic Retinopathy, by Processing the OCT Images

    Politehnica University
    Romania
    Biography

    Daniela Moraru is completing her Ph.D. studies in Bio-photonic and Optical Medical research fields at Politehnica University, Bucharest, within Academic Centre for Optical Engineering and Photonics, working also as Physics teacher. She graduated Physics Faculty, being specialized in Biophysics. She has several publications and presentations regarding some aspects of glycaemia influence on contrast sensitivity and on retinal thickness from bio-photonic point of view

    Abstract

    The study is based on OCT (Optical Coherence Tomography) images resulting from investigation of 24 patients (with a total of 33 eyes) with non-proliferative diabetic retinopathy and of 19 patients (with a total of 26 eyes) without diabetes mellitus as control group. Patients’ age was between 43 and 92 years old, with a mean age of 66.4 years for first group, and a mean age of 67.6 years for the second one. From this large group, after the first data evaluation, we selected patients aged 40 to 65. We evaluate daily each patient, at 9am, 12am, 3pm and 6pm, through glycaemic index level and OCT investigation using Macular Cube 512x128 images acquisition type. In the same time, we made specifically measurements of ISel (photoreceptor inner segment ellipsoid band) layer thickness using ImageJ soft. We analysed comparatively data given by OCT device and those obtained through direct thickness measurements for three macular zones: one central (foveola) and two circulars (para-foveola and peri-foveola), having 1mm, 3mm, respectively 6mm in diameter. We concluded that age and time of the day are significantly factors that influence the diabetic retinopathy. We also suggest this method as further investigation tool mostly for patients at the beginning of illness discovering, in order to diminishing and even stopping its evolution.

  • QT/QTc safety and efficacy evaluation of teneligliptin in Indian type 2 diabetes mellitus patients: the “thorough QT/QTc” study (Q-SET study)

    Diabetic Speciality Centre & Insulin Pump Centre Akshay Hospital
    India
    Biography

    Dr. Suhas Gopal Erande is a practicing consultant who is having own Diabetes centre & Insulin Pump Clinic at Akshaya Hospital, India. He has been writing Diabetes Patient Education books over 2 decades. Felicitated for social services for diabetes by ‘Diabetes Mitra’ award. He has written academic articles for physicians at National & International levels. Publications in National & International journals. He has been writing chapters in textbooks over years. Invited for poster presentation on Intensive Glucose Monitoring in Bethesda Baltimore 2016 Diabetes Technology Society Meet Invited for Global Diabetes Conference. For Diabetes in Women lecture in Prague August 2017. His recently published studies Prevalence of depression in T2DM in India(DEPTH study) & effect of teneligliptin on QT-QTc interval(Q SET study) have got International acclaim.

    Abstract

    Therapeutic armamentarium of T2DM has been rapidly expanding over last decade & dipeptidyl peptidase IV inhibitors (gliptins) have emerged as safe, efficacious, durable class. In this same timeframe, ADA-EASD guidelines have become more patient centric & the USFDA has given a mandate to prove cardiovascular safety before marketing any antidiabetic drug. Teneligliptin is a very widely used drug for T2DM in India since 2015. Therapeutic doses of teneligliptin(20 or 40 mg/day) have not been known to alter the QT interval in ECG, but, supratherapeutic doses(160mg/day) may prolong the same. Similar observations are made with sitagliptin (50 or 100 mg/d safe-but-400mg/d may prolong QT interval). Since prolongation of QT interval can increase risk of polymorphic ventricular tachyarrythmia Torsade de Pointes, this scrutiny is essential. Since there is no devoted study to assess if routine doses of teneligliptin(20 or 40mg/day) are safe with respect to effect on QT interval, we undertook this exercise. We selected 66 adult nonpregnant T2DM patients (age >18 yrs <65 yrs) who were gliptin naïve & on standard antidiabetic treatment, but, uncontrolled(HbA1c>7%). Teneligliptin 20mg/day was added to therapy & if needed, doubled to 40mg/day. Other drugs were unchanged through the study duration (unless compelling clinically). Baseline 12 lead ECG was recorded & also within 120 minutes of the 1st, 15th & 90th day of teneligliptin. Glycemic parameters were recorded alongwith other laboratory tests. QT interval was measured for each of these 4 ECGs (baseline, day 1, day 15 & 90) & QTc was calculated as per Bazett’s formula(QTc=QT/ sq root RR interval). It was observed that there was no increase in QT/QTc interval after 3 months of teneligliptin treatment(along with other antidiabetic drugs like glimepiride, pioglitazone, metformin). The drug improved glycemic parameters & without noteworthy adverse events. Larger studies & longer observation periods may help in future.

Advanced Technology and Tools for Diabetes | Contemporary Researches on Diabetes | Diabetes and Lifestyle
Chair
Co-Chair
Speaker
  • An introductory review of resistant starch type 2 from high-amylose cereal grains and its effect on glucose and insulin homeostasis
    Speaker
    Kathryn Harris
    Bay State Milling Company
    USA
    Biography

    Kathryn Harris is a Product Development and Nutrition Scientist at Bay State Milling Company, USA where she plays a key role in new product development of plant-based ingredients. With a Bachelor of Science degree in Food Science and Technology from the University of Massachusetts Amherst, USA and a Masters of Science degree in Human Nutrition and Functional Medicine from the University of Western States, USA Kathryn aspires to bridge the gaps between food science and nutrition communities. With a goal of delivering affordable food products that provide optimal nutrition to the consumer, Kathryn uses her experience from academia to read and dissect clinical nutrition research and apply that information to specific areas of food technology.

    Abstract

    Refined carbohydrates result from milling techniques that remove the outer layers of a cereal grain and grind the endosperm into a flour ingredient that is high in digestible starch and devoid of dietary fiber. The frequent use of refined grain flour in processed foods is contributing to the fiber deficient diet commonly followed in Western societies, which is believed to be associated with a number of non-communicable diseases such as Type 2 Diabetes. Technologies have been developed to produce high amylose cereal grains that have a significantly higher resistant starch type 2 and thus dietary fiber content in the endosperm of the cereal grain, which has positive implications for human health. A review of the literature was conducted to study the effects of resistant starch type 2 derived from high amylose grains on glucose and insulin response. While there are thousands of articles published on resistant starch, a total of 30 articles focused on how resistant starch type 2 from high amylose grains influenced acute and long term responses of glucose and insulin control. Results showed that resistant starch has the ability to attenuate acute postprandial responses when replacing rapidly digestible carbohydrate sources, but there is insufficient evidence to conclude that resistant starch can improve insulin resistance and/or sensitivity.

  • KLF15 Regulates Endobiotic and Xenobiotic Metabolism
    Speaker
    Shuxin Han
    Case Western Reserve University
    USA
    Biography

    Dr. Shuxin Han has been engaged in metabolic biology research for nearly 15 years. Dr. Han mainly studies the transcriptional regulation of metabolism by various transcription factors from previously nuclear receptors to currently kruppel-like factor (KLF) family. His recent academic achievements include three parts. First, Dr. Han opens a new research area of the KLF family regulation of endobiotic and xenobiotic metabolism. Second, Dr. Han discovers a novel patent therapeutic target for several human diseases such as liver injury and infertility. Third, Dr. Han expands and deepens the field of surgery metabolism.

    Abstract

    Hepatic metabolism and elimination of endobiotics (e.g., steroids, bile acids) and xenobiotics (e.g., drugs, toxins) is essential for health. While the enzymatic (termed phase I-II) and transport machinery (termed phase III) controlling endobiotic and xenobiotic metabolism (EXM) is known, our understanding of molecular nodal points that coordinate EXM function in physiology and disease remains incompletely understood. Here we show that the transcription factor Kruppel-like factor 15 (KLF15) regulates all three phases of the EXM system by direct and indirect pathways. Unbiased transcriptomic analyses coupled with validation studies in cells, human tissues, and animals, support direct transcriptional control of the EXM machinery by KLF15. Liver-specific deficiency of KLF15 (Li-KO) results in altered expression of numerous phase I-III targets, and renders animals resistant to the pathologic effect of bile acid and acetaminophen toxicity. Furthermore, Li-KO mice demonstrate enhanced degradation and elimination of endogenous steroid hormones, such as testosterone and glucocorticoid, resulting in reduced male fertility and blood glucose level, respectively. Viral reconstitution of hepatic KLF15 expression in Li-KO mice reverses these phenotypes. Our observations identify a previously unappreciated transcriptional pathway regulating metabolism and elimination of endobiotics and xenobiotics.

  • The effect of Sticopus hermanii- Hyperbaric Oxygen Therapy to osteogenesis of diabetic periodontiti
    Speaker
    Dian Mulawarmanti
    Universitas Hang Tuah
    Indonesia
    Biography

    Dian Mulawarmanti has completed her PhDs from Airlangga University, Indonesia. She is Associate professor of Universitas Hang Tuah Indonesia as a lecturer in faculty of dentistry. She got some national research grants from Directorate of Higher Education of Indonesoian Ministry of Education & Culture about Marine Biota and HBOT Research in Dentistry since 2013 –at present.

    Abstract

    Background : Diabetes and periodontitis affecting a large number of populations worldwide. Osteoprogeterin (OPG) is cytokine regulating osteoclastogenesis, related to osteoclast and osteoblast implicated in various inflammations including periodontitis and diabetes. Hyperbaric oxygen therapy (HBOT) has been used as adjuvant therapy to heal chronic wound problem. Sticopus Hermanii (SH) has been consumed as food rich with content of sulfated glycosaminoglycans (GAGs) which affect wound healing. The aim of this study is to examine the effect of HBOT and Sticopus hermanii to the exression of OPG, osteoclast and osteoblast in periodontitis diabetic rats. Methods and Material : The reasearch was an experimental laboratories with post test only control group design. Fourty five male Wistar rats aged 8-10 weeks were equally divided in 5 groups of : healthy group (G1), diabetic periodontitis group (G2), diabetic periodontitis group treated SH (G3), diabetic periodontitis group treated with HBOT 2,4 ATA 3x30’ interval 5’ for 7 days (G4), diabetic periodontitis group treated with combination SH-HBOT (G5). Diabetes was conducted by single dose of streptozotocin 65 mg/kg of BW intraperitoneal, while periodontitis were induced by Porphyromonas gingivalis ATCC 33277. The OPG expressions were examined by immunohistochemistry, while the number of osteoclast and osteoblast by hematoxylin eosin staining. Results : It was found that combination SH-HBOT (G5) in OPG could increased (12.50 ± 2.082) than diabetic-periodontitis group(G2) 2.50 ± 0.577. The combination SH-HBOT (G5) in osteoblast can increased significantly (28.47 ± 3.20) than diabetic-periodontitis group(G2) 9.22 ± 4.95. Osteoclast was decreased significantly in combination SH-HBOT (G5) 3.50 ± 0.957 than diabetic-periodontitis group diabetic-periodontitis group 0.500 ± 816. (p<0.05) Conclusion : HBOT increased OPG expression and osteoblast,reduced the number of osteoclast in periodontitis diabetic rats Keywords : OPG, osteoclast, osteoclast, diabetes, periodontitis

  • Application of Data Analytics in Healthcare to Serve the Mankind
    Speaker
    Mamatha Bai B G
    Nitte Meenakshi Institute of Technology
    India
    Biography

    Ms. Mamatha Bai B G got her Bachelor of Engineering and Master of Technology Degree from VTU. She is currently working as Assistant Professor in the Dept. of M. Tech CSE, Nitte Meenakshi Institute of Technology, Bengaluru, Karnataka, India. Her Research Interests include Big Data Analytics, Wireless Sensor Networks and Data Mining.

    Abstract

    As we are the era of rapid technological advancement, the data is increasing rapidly and the emerging technologies are used for a better solution. Due to the busy lifestyle, the focus and care on the health issues is neglected and is leading to severe health concerns at a later stage if not properly monitored and detected at an early stage. To overcome this problem and create an awareness among the individuals, a research is proposed to serve the Mankind using Data Analytics. Data Analytics involves a large volume and variety of data and helps us to examine the medical data and draw timely conclusions so that the patients can be sent regular alerts based on monitoring their health conditions. This work also helps the doctors to diagnose the disease at an early stage and prevents the patients from suffering at a later stage by adopting smart decision and right management techniques.

Case studies on Diabetes | Risk Factors and Related Diseases of Diabetes | Diabetes- Nutritional Diet, Exercise and Metabolism | Gestational Diabetes
Chair
Co-Chair
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  • A Comparative Study of Muscle Symptoms of Atorvastatin with Rosuvastatin in Patients of Atherosclerotic Cardiovascular Disease
    Speaker
    Rakibul Hasan Rashed
    Bangabandhu Sheikh Mujib Medical University
    Bangladesh
    Biography

    Dr Md Rakibul Hasan Rashed has completed my Doctor of Medicine in (MD) in Cardiology in July, 2018 from Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. He is acting as Assistant Registrar in Department of Cardiology, Rajshahi Medical College Hospital, Rajshahi, Bangladesh. He has over 6 publications that have been citied over 10 times. He is now working in a place where potential source of data exit regarding different medical issues, specially cardiology and endocrine subject. He has interest on research of medical science to contribute a bit in my sector.

    Abstract

    Statins are the corner stone therapy of atherosclerotic cardiovascular disease (ASCVD). Statin may cause myalgia, myotoxicity, myopathy and rhabdomyolysis along with its lipid lowering properties and pleiotropic effects. Statins associated muscle symptoms (SAMS) are the leading cause of nonadherent and discontinuation. This study was conducted to evaluate and understand the muscle symptoms of high intensity statin therapy (atorvastatin 40 mg and rosuvastatin 20 mg) for a period of three months in individual patient with clinical atherosclerotic cardiovascular disease. A total of 280 patients with clinical atherosclerotic cardiovascular disease were studied to once daily atorvastatin 40 mg and rosuvastatin 20 mg. It was a randomized controlled single blind trial. The primary end point was muscle symptoms-muscle pain, fatigue, cramp/spasticity and weakness at 4 weeks and in 3 months of study period. Serum creatinine kinase was measured in every patient with muscular symptoms. Patients of atorvastatin group noticed severe pain more than rosuvastatin group at the end of 4 weeks and 3 months of treatment period respectively. Significantly more patients felt extremely bad and bad with atorvastatin compared with rosuvastatin. Patients of atorvastatin group showed more marked increase muscle spasm than rosuvastatin group by spasticity grade. Three patients of atorvastatin group developed grade 3 muscle power. Serum creatine kinase > 1500 U/L was observed more in atorvastatin than rosuvastatin group. Statin associated muscle symptoms (more severe muscle problem, myositis/myopathy) observed more in atorvastatin than that of rosuvastatin group. Both treatments were well tolerated. No cases of rhabdomyolysis, incident diabetes, hepatic or renal insufficiency were recorded during the study period. Rosuvastatin had better outcome profile of muscle symptoms than atorvastatin in patients with clinical atherosclerotic cardiovascular disease among the Bangladeshi population

  • Evaluation of the health seeking practices among diabetics (>10 years of duration) in the field practice areas of government medical college, Amritsar
    Speaker
    Mohan Lal
    Government Medical College Amritsar
    India
    Biography

    Postgraduate (MD) in Community Medicine & Post Graduate Diploma in Hospital & Health Management. Worked about 10 years in Regional Health and Family Welfare Training Center. Published two books 1. Women & Child Health Care (Vernacular Language) 2. Let’s know about Health problems! (Vernacular Language). Worked with John Hopkins School of Public Health in Road Safety -10 Project. Principal Investigator for a Multicentric Study at National Level. Currently involved as an investigator in Project “Burden of NCD risk factors in Punjab, India. According to Researchgate, RG score is 16.85 He has 46 publications that have been cited 50 times, and his publication H –index is 2 and has been serving as a reviewer member of journals. Worked as Supervisor (7) and Co- supervisor (6) for thesis work. Nodal officer for state level capacity building training for medical officers. Member Secretary, Academic College Council, Secretary, IAPSM, Punjab Chapter.

    Abstract

    Diabetes has become global issue due to premature illness and it’s complications leading to death. Epidemiological transitions and demographic transitions in developing countries are contributing to this rise. Though the problem reigns in both developing and developed countries, it is the former which suffers the most due to lack of awareness. Awareness about good health seeking practices are essential for prevention, early diagnosis and management of diabetic complications. This study was conducted to evaluate the health seeking practices among diabetics in the field practice areas (rural and urban) of Government Medical College, Amritsar. A community based cross-sectional study was carried out in both rural and urban areas of district, Amritsar. A total of 200 diabetic patients who had diabetes equal to or more than 10 years of duration were interviewed using pretested and predesigned questionnaire. Data such collected was analysed at p <0.05. Out of total 200 diabetic respondents, 50% (100) were from urban and 50% (100) were from the rural area. In both urban and rural areas, majority were literate i.e. 80% (161) and employed i.e. 51% (103). The mean age of diabetic respondents was 58.05 years with a male to female ratio of 1.1:1. The majority 82% (165) were diagnosed in the private sector and 99% (198) were on allopathic treatment. Oral hypoglycaemic agents were used by 77% (153) patients to manage their disease. 23% (45) were using both oral hypoglycaemic agents and insulin. About 48% (96) were monitoring their RBS regularly, 76% (151) were on regular treatment for diabetes and 55 (27%) were doing physical activity. Lack of awareness and poor health seeking practices and about non pharmacological measures are main factors for development of complications among diabetic patients.

  • Clinical study on risk factors and fetomaternal outcome of severe pre-eclampsia in Bangabandhu Sheikh Mujib Medical University
    Speaker
    Aklima Sultana
    Chattogram Maa O Shishu Hospital Medical College
    Bangladesh
    Biography

    Dr. Aklima Sultana has completed her Fellowship in Gynaecology and Obstetrics at the age of 33 She is trained in basic and advanced laparoscopy both from nation and abroad. She also has basic training on colposcopy . Currently is an assistant professor of Obstetrics and Gynaecology at Chattogram Maa O Shishu Hospital Medical College where she teaches medical students and manages over 350 patients per week.

    Abstract

    Background: Pre-eclampsia (PE) is a leading cause of morbidity and mortality among mothers and infants. The aim of this study was to determine the maternal risk factors and fetomaternal outcome of severe pre-elampsia. Methods: A total of 100 patients were recruited. Patients with singleton pregnancy between 28 to 40 weeks of gestation with severe pre-eclampsia were selected as cases. A questionnaire including patient’s age, gestational age, parity, family history of hypertension, weight and body mass index (BMI), was completed for each patient. Maternal complications before or after delivery, and perinatal outcome were also recorded. And finally data analysis was done. Results: Among cases and controls, age>34 years, BMI, history of preeclampsia, were found significant (p<0.05) between the two groups. In case group, 2 patients developed eclampsia, 3 abruptio placenta, 2 HELLP syndrome, 4 ascites, and 1 oliguria ; 7 patients developed PPH and 3 pulmonary edema. In the control group, 5 developed PPH and 1pulmonary edema. In case group, 5 babies had very low birth weight (<1.5 kg) and 21 had low birth weight (<2.5 kg). In control group only 8.0% had low birth weight. 56.0% had APGAR score 4-6 at one minute in case group and 24.0% in control group. In case group 17 babies developed birth asphyxia and 15 babies developed prematurity, where as in control group 7 babies developed birth asphyxia and 3 developed prematurity. 32 newborns needed admission in NICU in cases and 10 in controls (p<0.05). 35 babies could be taken home safely in case group as compared to all babies in control group. Early neonatal death was found in 5 and still birth in 10 in case group; none found in control group (p< 0.05). Conclusion: Maternal and fetal outcome are worse in sever preeclampsia. Keywords: feto-maternal outcome, Preeclampsia, Pregnant woman. Morbidity and mortality

  • Prevalence of erectile dysfunction among Egyptian male patients with type 2 diabetes mellitus
    Speaker
    Mohammed Zeitoun
    Alexandria University
    Egypt
    Biography

    Mohammed Zeitoun, MD, is currently a lecturer at the Department of Diabetes & Metabolism, Faculty of Medicine, Alexandria University, Egypt. He received his Doctorate of Internal Medicine (Diabetes & Metabolism) from Alexandria University in 2013. As one of the top international raising stars in the field of diabetology, in 2015, Dr Zeitoun was honored as a “Donnell D. Etzwiler International Scholar” recipient and accordingly he attended a special program at the International Diabetes Centre in Minneapolis, Minnesota, United States and the Mayo Clinic in Rochester, Minnesota, United States. In 2017 he received a Post Graduate Diploma in Diabetes, Cardiff University. Dr Zeitoun is a recognized educator and has given more than 100 continuing medical education (CME) talks to audiences comprising endocrinologists, internists, family physicians, residents and diabetes educators in Egypt and abroad. Dr Zeitoun has publications in national and international peer-reviewed journals and presented posters in national and international congresses.

    Abstract

    OBJECTIVES: The relation between type 2 diabetes mellitus (T2DM) and erectile dysfunction (ED) has been identified in multiple studies. The aim of this study was to estimate the prevalence of ED among a sample of adult Egyptian male patients with T2DM. SUBJECTS AND METHODS: This cross-sectional study included 150 adult male patients with T2DM (aged 40-60 years) who attended the outpatient clinic of Diabetes in Alexandria Main University hospital. They were evaluated for the presence of ED which was assessed by the validated Arabic-translated five-item version of the International Index of Erectile Function-5 (IIEF-5) questionnaire. Fasting blood glucose (FBG), HbA1c, total serum cholesterol, HDL-C, total serum testosterone (TT) and urinary albumin creatinine ratio (ACR) were measured for all study subjects. RESULTS: The prevalence of ED was 80% among the studied sample. Significant negative correlation was found between ED and age, duration of diabetes, urinary ACR, TT and FBG. On performing multiple linear regression analysis for the parameters affecting (IIEF-5) questionnaire score, TT, urinary ACR, age and FBG were the predictors of ED. CONCLUSION: ED was a common finding in our sample of Egyptian men with T2DM. The relation between albuminuria and ED was an interesting finding and requires further exploration

Young Research Forum
Speaker
  • Facilitating and Evaluating the Impact of Technology-enabled Specialist Diabetes Care Delivery to Care Homes
    Speaker
    Rebecca Matthews
    University of the Highlands and Islands
    United Kingdom
    Biography

    Rebecca has completed 3 years of her PhD and is currently concluding the last 6 months at the University of the Highlands and Islands in Inverness, Scotland, United Kingdom. “Diabetes, Care Homes and the Influence of Technology on Practice and Care Delivery in Care Homes: Systematic Review and Qualitative Synthesis” was published in JMIR in April 2019. Rebecca has been a student with the University of the Highlands and Islands since 2008 when training to become a Registered Adult Nurse, continuing to complete a 2 year Masters Degree in Care of the Older Person. She then spent 2 years in practice working as a healthcare professional within the public and private sectors of acute, community and care home settings.

    Abstract

    Diabetes is increasing in prevalence and complexity in the care home setting, affecting up to 27% of care home residents in the United Kingdom. Health outcomes for these residents are impacted by management of the disease, healthcare professionals’ decision-making skills within the care home setting, and, access to specialist services. This project focuses on the use of technology having the potential to recognise opportunities for early intervention enabling efficient responsive care, taking a fundamental role in linking the care home community to wider specialist services and multi-disciplinary teams for support. By triangulating the perspectives of the care home community, it is anticipated that this project will represent an up to date, evidenced-based overview of the potential for using technology within the care home setting for diabetes management, education and training, as well as stimulate research in this area. Five studies study have been completed with each study informing the next, commencing with a Systematic Review of the literature to give a wider understanding of technologies already being used, followed by questionnaires to 71 care homes within the Highlands and Islands as part of a service evaluation, a focus group with the Community Diabetes Specialist Nurses to gain expert opinion, and, 28 one-to-one interviews with care home staff across the Highlands and Islands to understand their perspectives. These studies lead to the final study of facilitating and evaluating an intervention in practice with care home staff led by a Community Diabetes Specialist Nurse and Specialist Dietician.

  • Study of Birth Complications in Diabetic Mothers
    Speaker
    Hafiz Hafeez Ullah
    The Indus Hospital Kahna Nau
    Pakistan
    Biography

    Hafiz Hafeez Ullah, has completed his Pharm. D at the age of 25 years from Hajvery University, Lahore, Pakistan. He is the Hospital Pharmacist at “The Indus Hospital Kahna Nau, Lahore, Pakistan”.

    Abstract

    The current study was being performed to evaluate the birth complications in diabetic mothers; including both maternal and fetal complications; miscarriages. The nature of study was observational cross-sectional. The study was being taken place at different hospitals, clinical settings, and maternity homes of Lahore during September 2016 - November 2016. The demographic data, family history, socio-economic history, indications, examination findings, results, lab findings etc were recorded. Total 200 pregnant diabetic patients were evaluated for this study. The age limit for this study was 18-40 years. The patients were being analyzed for their FBS/BSR or HbA1cfindings and the type of diabetes was being recorded. Out of 200 patients, 81% had GDM while the remaining patients were being presented with pre-gestational diabetes (type I 5%, type II 14% patients). Most of the GDM cases were being diagnosed during 5th to 8th week of pregnancy. Out of 200 pregnancies, 20.5% (41) of these patients had normal pregnancies, and had no major fetal complications except uncontrolled sugar level in mothers. Remaining 79.5% (159) pregnancies/deliveries were associated with some major complications including respiratory distress, macrosomia, hypoglycemic babies, CVS malformations and still births/miscarriages. The ratio of normal vaginal delivery to CS was found out to be 29% to & 76%. The major indications for these CS deliveries were placental abruption (19.74%), dystocia (14.47%), uterine rupture (13.16%), breech position (6.58%), fetal distress (46.05%) and to some extent previous CS. The miscarriages were being associated with hypertension (41.5%), polyhydramnios (22%), Hughes syndrome (12.2%), and uncontrolled sugar level (24.3%). In our study population TT immunization status was good i.e. 76%. Diabetes is still a major problem of birth complications and miscarriages. Public awareness program is required to educate the people about reproductive health and to motivate them to undergo BSR/FBS during pregnancy prior to 24thgestational weeks to diagnose for GDM. KEY WORDS: Pregnancy, Complications, Diabetes, GDM, Neonate, Fetus, Miscarriage

Poster Presentation
Speaker
  • Investigation of molecular mechanism of glucose-lowering activity of Aquilaria crassna L. leave extract in HepG2 cells
    Speaker
    Phanupol Mongkolsiri
    Mahidol University
    Thailand
    Biography

    Phanupol Mongkolsiri is a graduate student in the Biochemistry Program at Mahidol University where he investigates biolochemical activities of natural products which may be used as anti-diabetic drugs. He completed his B.Sc. in Chemistry from Mahasarakham University.

    Abstract

    Type 2 diabetes mellitus is a chronic metabolic syndrome characterized by hyperglycemia which can further develop microvascular and macrovascular complications. Aquilaria crassna L. was reported as a traditional Thai medicinal plant that possesses an anti-diabetic effect in animal model. The present study revealed the mechanism by which this plant extract lowered glucose levels in cultured hepatocellular cell line, HepG2. ALE at a concentration of 6.25, 12.5 and 25 µg/mL significantly increased glucose consumption in a dose- dependent manner. The increase of glucose consumption of ALE-treated HepG2 cells was accompanied by 2-fold increase of the glycogen synthase 2 (GYS-2) mRNA expression and 50% suppressing of glucose-6-phosphatase expression. These data indicate that the anti-diabetic effect of ALE on HepG2 cells is mediated through the increased of glycogen synthesis and the decrease of gluconeogenesis. Gas-chromatography and mass spectrometry (GC-MS) analysis of the ethanolic extract of ALE consisted of nitrogen containing compounds (39%), terpenoids (31%), polyketide (18%), and phenylpropanoids (12%). Investigation of glucose-lowering effect of these compounds is currently underway.

  • The Association between Osteoporosis and Micro vacular Complications among egyptian type 2 diabetic patients
    Speaker
    Hytham Badr
    Menoufia University
    Egypt
    Biography

    Lecturer of diabetes and endocrinology, Menoufia University, Egypt MD of internal medicine, 2019 Master of internal medicine, 2016

    Abstract

    Objectives: Diabetes mellitus may adversely influence the bone quality through the regulation of bone cells. However, several studies have demonstrated increased risk of fracture in diabetic patients in spite of normal or even higher bone mass density BMD. The aim of this study was to evaluate the association between osteoporosis and micro vascular complications among Egyptian type 2 diabetic patients. Methods: A prospective study of 78 patients with T2DM was enrolled. They were classified into two groups. Group I (Micro vascular group) included 39 diabetic patients with microvasular complications. Group II (control group) included 39 patients without microvasular complications. Group I was subdivided into 3 subgroups according to the number of microvasular complications. Age, gender, duration of diabetes, hypertension and BMI were documented. FBS, 2hPPBG, foot examination, Fundus examination and Albumin /creatinine ratio were calculated. Dual Energy X-ray Absorptiometry (DEXA) and serum osteocalcin were done to both studied groups. Results: There was no significant difference between the two studied groups in the DEXA scan results, the mean least T score of the microvasular group was -1.4 and that of the control group was -1.2 (P value = 0.27). The mean osteocalcin level of the micro vascular group was 35.8, while that of the control group was 13.8 showing significant difference between the two groups (P value = 0.03). The mean osteocalcin level of the microvascular1 subgroup was 17.8, that of the microvascular2 subgroup was 23.04 and that of the microvascular3 subgroup was 45.4 showing highly significant difference between the three subgroups (P value < 0.001). Conclusion: Osteoporosis diagnosed by elevated level of serum osteocalcin is more prevalent in T2DM with microvascular complications and its prevalence increases with the increased number of these complications. However, DEXA scan is not reliable in diagnosis of osteoporosis.

Video Presentation
Speaker
  • Hybrid Approach by using Hybrid-TBP for Tuberculosis Drug Resistance analysis
    Speaker
    Maji S
    DIT University
    India
    Biography

    Maji S has completed her PhD from Thapar University, India in the year 2013. She is presently working as the Assistant professor at DIT University, Dehradun, India. She has large number of publications that have been cited over 60 times, and his/her publication H-index is 5 and has been serving as a reviewer of reputed Journals.

    Abstract

    Timely correct and rapid prediction of Mycobacterium tuberculosis (MTB) resistance against available tuberculosis (TB) drugs is crucial for control and management of the TB. Various machine learning methods have been largely applied for timely predicting resistance of MTB given a specific drug and identifying resistance markers. Even though, they are not properly validated in the large group of MTB samples across the globe in terms of resistance prediction and resistance marker identification. Our proposed Hybrid Machine technique named Hybrid-TBP can be used for the identification of Mycobacterium tuberculosis (MTB) resistance beside numerous existing TB drugs for the management and control of TB. In this hybrid machine learning tool initial data samples of MTB data samples is provided to the Principle Component Analysis (PCA) for feature selection and classification is performed for result generation by using Support Vector Machine (SVM) with polynomial kernel. This Hybrid-TBP can be utilized as a supporting software tools in the field of medical science for MTB resistance. As compared to other existing available software MTB prediction tools, this proposed technique gives better performance.

Day 2

Thanks Giving & Closing Ceremony
B2B Networking & Lunch

Mail us at

Program Enquiry
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Terms and Conditions

Responsibility

The organizers hold no responsibilities or liabilities of the personal articles of attendees at the venue against any kind of theft, loss, damage, due to any reason whatsoever. Delegates are entirely responsible for the safety of their own belongings.

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Please note that transportation and parking is the responsibility of the registrant, Allied Academies will not be liable for any actions howsoever related to transportation and parking.

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For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference after payment of complete registration fee. Once registration is complete, please contact diabetes@alliedgather.com to request for a personalized letter of invitation, if not received until one month before the scheduled date of the event.

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Cancellation Policy

All cancellations or modifications of registration must be made in writing to finance@alliedacademies.com

If due to any reason, Allied academies postpone an event on the scheduled date, the participant is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within a period of one year from the date of rescheduling. 

Postponement of event

If due to any reason, Allied academies postpone an event and the participant is unable or unwilling to attend the conference on rescheduled dates, he/she is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within a period of one year from the date of rescheduling.

Transfer of registration

All registrations, after payment of complete registration fee, are transferable to other persons from the same organization, if in case the person is unable to attend the event. Request for transfer of registration must be made by the registered person in writing to finance@alliedacademies.com. Details must include the full name of the replaced new registrant, their title, contact phone number, and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied academies if the person is unable to attend one of the conferences.

However, Registration cannot be transferred if intimated within 14 days of the respective conference.

The transferred registrations will not be eligible for Refund.

This cancellation policy was last updated on April 04, 2015.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues are not covered under the cancellation policy of Allied academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend and is not in a position to transfer his/her participation to another person or event, then the following refund policies apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overhead charges, following Refund Policy Orders are available:

  • Before 60 days of the conference: Eligible for Full Refund after deduction of $100 towards service Fee.
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Accommodation Cancellation Policy:

Accommodation Service Providers (Hotels) have their own cancellation policies which are applicable when cancellations are made less than 30 days prior to arrival. If in case the registrant wishes to cancel or amend the accommodation, he/ she is expected to inform the organizing authorities on a prior basis. Allied academies will advise the registrant to ensure complete awareness about the cancellation policy of your accommodation provider, prior to cancellation or modification of their booking.

Highlights from last year's Convention

Authorization Policy


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